Outfitting your R with the proper add-ons

R add-on packages are available to install directly from R:

> install.packages("optmatch")

Thi command will ask you to select a CRAN server. Any server will do. You may also be asked whether you’d like to set up a “personal library to install packages into”; if so, answer yes. (The default personal library location that R will suggest should be OK.) You’ll only need to run these commands the first time you want to use optmatch on a particular computer, or when you install a new version of R.

Setting up the R environment for matching

Attach extension packages that we’ll be using for matching and associated diagnostics:

> library(optmatch)

You’ll do this each time you start a new R session and want to run matching commands.

To load the nuclear plants data, enter

> data(nuclearplants)

To see the first six rows:

> head(nuclearplants)
##     cost  date t1 t2  cap pr ne ct bw cum.n pt
## H 460.05 68.58 14 46  687  0  1  0  0    14  0
## I 452.99 67.33 10 73 1065  0  0  1  0     1  0
## A 443.22 67.33 10 85 1065  1  0  1  0     1  0
## J 652.32 68.00 11 67 1065  0  1  1  0    12  0
## B 642.23 68.00 11 78 1065  1  1  1  0    12  0
## K 345.39 67.92 13 51  514  0  1  1  0     3  0

For more on the variables here, enter

> help("nuclearplants")

You can directly access a variable within this data frame as follows. (Try typing in the commands to see what they do.)

> nuclearplants$pt
> table(nuclearplants$pt)
> with(nuclearplants, table(pt))

The variable you will have just viewed and tabulated, pt, is a dummy for whether the plant was built with “partial turnkey guarantees.” These plants were not comparable to the others in terms of construction costs. Let’s exclude them for the time being, for simplicity. To do this we’ll create a data table (in R jargon, a “data frame”) of just those observations for which pt is 0:

> nuke.nopt <- subset(nuclearplants, pt == 0)

To inspect its first six or last six entries, do

> head(nuke.nopt)
> tail(nuke.nopt)

To view this as presenting a matching problem, we’ll think of plants built on the site of a previously existing plant (pr == 1) as the treatment group and plants on new sites (pr == 0) as comparisons.

Pair matching

To check the number of treated and control plants:

> table(nuke.nopt$pr)
## 
##  0  1 
## 19  7

To get the pair match minimizing the mean paired distance on cap, among all collections of 7 non-overlapping pairs, do

> pairmatch(pr ~ cap, data = nuke.nopt)
##    H    I    A    J    B    K    L    M    C    N    O    P    Q    R    S    T 
## <NA>  1.1  1.1  1.2  1.2 <NA>  1.7 <NA>  1.3 <NA> <NA> <NA>  1.4  1.5  1.3 <NA> 
##    U    D    V    E    W    F    X    G    Y    Z 
##  1.6  1.4 <NA>  1.5 <NA>  1.6 <NA>  1.7 <NA> <NA>

For a more readable report of who gets matched to whom, type

> print(pairmatch(pr ~ cap, data = nuke.nopt), grouped = TRUE)
##  Group Members
##    1.1    I, A
##    1.2    J, B
##    1.3    C, S
##    1.4    Q, D
##    1.5    R, E
##    1.6    U, F
##    1.7    L, G

For matching on both date and cap, you’d type pairmatch(pr ~ cap + date, ...) instead of pairmatch(pr ~ cap, ...). We’ll talk later about how this combines discrepancies on the two variables. For now, note the form of the output this command generates: a variable of the same length as the variables making up nuke.nopt, assigning a distinct name to each matched set. To fix your intuition, you might try connecting up below the units that pairmatch() has placed in the same matched sets.

For basic summary information about this match, try

> summary(pairmatch(pr ~ cap, data = nuke.nopt))

If you’ve already typed in the pairmatch(...) part, you can use the up-arrow, Home and End keys to avoid having to re-type. Alternatively, to assign the name “pm” to the matching result, do

> pm <- pairmatch(pr ~ cap, data = nuke.nopt)

Now, you can just type print(pm, grouped = TRUE) or summary(pm).

The following would give a basic matched analysis of the effect of new or existing site on construction costs is given with the help of R’s linear modeling function. In effect, the existing site effect is estimated as one “way” in a two-way , the other “way” being the factor variable that represents the matching result, i.e. pm.

> summary(lm(cost ~ pr + pm, data = nuke.nopt))

Matching with multiple controls

There are other types of matches you might want to try. Here’s how to create matched triples (each treatment group unit is matched to two control group units):

> tm <- pairmatch(pr ~ cap, controls = 2, data = nuke.nopt)

Did matching work?

It’s possible to give the software an impossible list of requirements for a match. For instance, try running the following:

> pairmatch(pr ~ cap, controls = 3, data=nuke.nopt)

The problem here is that the data don’t have 3 comparison units to go with each treatment unit, since we have 7 treatment units but only 19 comparison units.

Matching can also fail because the distance matrix embodies matching constraints that are impossible to meet. In these cases the matching function will generally run without complaint, although it won’t create any matches. Here is an example, where the caliper is so narrow as to forbid all possible matches:

> pairmatch(pr ~ cap + cost, caliper=.001, data = nuke.nopt)
## Warning in fullmatch.InfinitySparseMatrix(x = x, min.controls = controls, : Matching failed. (Restrictions impossible to meet?)
##  Enter ?matchfailed for more info.
##    H    I    A    J    B    K    L    M    C    N    O    P    Q    R    S    T 
## <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> 
##    U    D    V    E    W    F    X    G    Y    Z 
## <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA>

Behind the scenes, the caliper argument restricts how the maximum distance between matched objects. For example, consider Table 1 above. Plants A and H are 1.3 units apart in date. If we assigned caliper=1, they could never be matched because they exceed the caliper limit.

If before matching you want to remove just the subjects lacking a counterpart within caliper distance, you can do pairmatch(..., remove.unmatchables = TRUE). That won’t help with the minuscule caliper above, but with less extreme calipers it helps you salvage a few matches.

Did matching balance the covariate?

Comparing overt biases before and after matching. An assessment of the unmatched difference between the groups on cap can be had via:

> cap.noadj <- lm(cap ~ pr, data = nuke.nopt)
> summary(cap.noadj)

The output is suppressed, as most of it is not relevant to balance. This variation hones in on the part that is:

> summary(lm(cap ~ pr, data = nuke.nopt))$coeff["pr",]
##   Estimate Std. Error    t value   Pr(>|t|) 
## 79.7368421 92.7031668  0.8601307  0.3982280

(Note again the use of square brackets, [ and ], for specifying subsets of a matrix. With R one has to carefully distinguish square brackets, curly brackets and parentheses.)

Here is a parallel calculation that takes the match pm into account.

> summary(lm(cap ~ pr + pm, data = nuke.nopt))$coeff["pr",]
##   Estimate Std. Error    t value   Pr(>|t|) 
## -6.5714286  4.2865079 -1.5330495  0.1761543

The RItools package’s RItools::balanceTest() function zeroes in on balance, and facilitates checking balance on multiple variables at the same time. Here are some examples:

> install.packages("RItools")
> library(RItools)
> balanceTest(pr ~ cap + t2, data = nuke.nopt)

##      strata():        --                                        
##      stat      Treatment Control adj.diff std.diff    z         
## vars                                                            
## cap                883     803       79.7    0.39    0.86       
## t2                 66.9    59.5      7.33    0.68    1.61       
## ---Overall Test---
##    chisquare df p.value
## --      2.71  2   0.258
## ---
## Signif. codes:  0 '***' 0.001 '** ' 0.01 '*  ' 0.05 '.  ' 0.1 '   ' 1

> balanceTest(pr ~ cap + t2 + strata(pm) - 1, data = nuke.nopt)
> # The `- 1` suppresses the unmatched output to make the output cleaner

##      strata():        pm                                         
##      stat      Treatment Control adj.diff std.diff    z          
## vars                                                             
## cap               883     890       -6.57   -0.03   -1.40        
## t2                66.9    61.3      5.57     0.54    1.49        
## ---Overall Test---
##    chisquare df p.value
## pm      6.73  2  0.0345
## ---
## Signif. codes:  0 '***' 0.001 '** ' 0.01 '*  ' 0.05 '.  ' 0.1 '   ' 1

Exercises.

1. Compare pm, tm and the unmatched samples in terms of balance on t2.
2. Compare pm, tm and the unmatched samples in terms of balance on date.
3. Compare pm to Mahalanobis pair matching on t1 in terms of balance on date.
4. Compare Mahalanobis pair matching on cap and date to Mahalanobis pair matching on cap, date and each of t1,t2. Add the last two variables in one at a time, so that you’re comparing a total of three matches. Compare on balance in cap and t2.

Section “Checking balance in general”, below, presents convenient ways to do balance assessment for many variables at once. Before getting to that let’s discuss try matching with propensity scores.

Propensity score fitting in R

Logistic regression models are fit in R using the function glm(), with family argument set to binomial. Example:

> psm <- glm(pr ~ date + t1 + t2 + cap + ne + ct + bw + cum.n + pt,
+            family = binomial, data = nuclearplants)

The fitted logistic regression is then stored in the object psm. The propensity scores can be accessed with psm$fitted.values (estimated probabilities) or scores(psm) (estimated logits of probabilities).

It’s often a good idea to compare the groups’ distributions on the propensity score.

> boxplot(psm)

The groups do overlap, if not greatly. It may be wise to restrict the sample to the region of overlap, at least roughly. A propensity caliper would help with this.

First, let’s match directly on the propensity score without restricting the sample to the region of overlap.

> ps.pm <- pairmatch(psm, data = nuclearplants)
> summary(ps.pm)
## Structure of matched sets:
## 1:1 0:1 
##  10  12 
## Effective Sample Size:  10 
## (equivalent number of matched pairs).

To restrict to the overlapping region, we want to imply a caliper to the distances generated by the propensity score model. To do this requires a more explicit generation of the match, involving separate steps for generation of the distances followed by matching upon those distances.

First, we create a distance matrix based upon psm:

> psm.dist <- match_on(psm, data=nuclearplants)

psm.dist is a matrix with an entry corresponding to the distance between each potential pair of treatment and control units. We can caliper directly on this distance matrix,

> caliper(psm.dist, 2)
##        control
## treated   H   I   J   K   L   M   N   O   P   Q   R   S   T U   V   W   X   Y
##       A Inf Inf Inf Inf Inf Inf Inf Inf Inf Inf Inf Inf Inf 0   0 Inf Inf Inf
##       B Inf   0 Inf Inf Inf   0   0   0 Inf   0   0   0   0 0   0   0 Inf Inf
##       C Inf   0   0 Inf Inf   0   0   0 Inf   0   0   0   0 0 Inf   0   0 Inf
##       D Inf Inf Inf Inf Inf Inf Inf Inf Inf Inf Inf   0 Inf 0   0 Inf Inf Inf
##       E Inf   0 Inf Inf Inf   0   0   0 Inf   0   0   0   0 0   0   0   0 Inf
##       F Inf   0 Inf Inf Inf   0 Inf   0 Inf Inf   0   0   0 0   0 Inf Inf Inf
##       G Inf   0 Inf Inf Inf   0   0   0 Inf   0   0   0   0 0   0   0 Inf Inf
##       a Inf   0 Inf Inf Inf Inf Inf Inf Inf Inf   0   0   0 0   0 Inf Inf Inf
##       b Inf Inf Inf Inf Inf Inf Inf Inf Inf Inf Inf Inf Inf 0   0 Inf Inf Inf
##       c Inf   0 Inf Inf Inf   0   0   0 Inf   0   0   0   0 0   0   0 Inf Inf
##        control
## treated   Z d   e   f
##       A Inf 0 Inf Inf
##       B   0 0 Inf   0
##       C   0 0 Inf   0
##       D Inf 0 Inf Inf
##       E   0 0 Inf   0
##       F   0 0 Inf   0
##       G   0 0 Inf   0
##       a   0 0 Inf   0
##       b Inf 0 Inf Inf
##       c   0 0 Inf   0

Entries which are Inf will never be matched. Adding the caliper to psm.dist will disallow matching between units which differ by more than 2 standard deviations.

(Note that this differs from the previous use of caliper directly in pairmatch, where the caliper is applied directly to the distances instead of smartly upon the standard deviations between the propensity scores.)

Combining the above, we can now

> ps.pm2 <- pairmatch(psm.dist, data = nuclearplants)
> ps.pm3 <- pairmatch(psm.dist + caliper(psm.dist, 2), data = nuclearplants)
> all.equal(ps.pm, ps.pm2, check.attributes=FALSE)
## [1] TRUE
> all.equal(ps.pm, ps.pm3, check.attributes=FALSE)
## [1] "7 string mismatches"
> summary(ps.pm3)
## Structure of matched sets:
## 1:1 0:1 
##  10  12 
## Effective Sample Size:  10 
## (equivalent number of matched pairs).

Or you could match within calipers of the propensity score on some other distance, perhaps Mahalanobis distances based on selected covariates as recommended by Rubin and Thomas (2000, JASA) and others. For Mahalanobis matching on date, cap and the propensity score, for instance, combined with a propensity caliper of 1 pooled sd.

> mhd1 <- match_on(pr ~ date + cap + scores(psm), data=nuclearplants)
> mhpc.pm <- pairmatch(mhd1, caliper=1, data=nuclearplants)
> summary(mhpc.pm) # oops
## Structure of matched sets:
## 1:1 0:1 
##  10  12 
## Effective Sample Size:  10 
## (equivalent number of matched pairs).
> mhpc.pm <- pairmatch(mhd1, caliper=2, data=nuclearplants)
> summary(mhpc.pm) # better!
## Structure of matched sets:
## 1:1 0:1 
##  10  12 
## Effective Sample Size:  10 
## (equivalent number of matched pairs).

Checking balance in general

The RItools package has a convenient function for checking balance on many variables simultaneously. To get a sense of what it does, try this:

> balanceTest(pr ~ date + t1 + t2 + cap + ne + ct + bw + cum.n,
+             data = nuclearplants)
> balanceTest(pr ~ date + t1 + t2 + cap + ne + ct + bw + cum.n + pt +
+               strata(ps.pm2) - 1,
+             data = nuclearplants)

It can in the same display compare matching to no matching, on any of a number of axes. Here is a demonstration:

> myb <- balanceTest(pr ~ date + t1 + t2 + cap + ne + ct + bw + cum.n +
+                      strata(ps.pm2),
+                    data = nuclearplants)
> plot(myb)
> print(myb, digits=1)

##       strata():    ps.pm2                                                --                                        
##       stat      Treatment Control adj.diff std.diff    z          Treatment Control adj.diff std.diff    z         
## vars                                                                                                               
## date                68      69       -0.2     0        0              68      69       -0.1     0        0         
## t1                  14      14       -0.3     0        0              14      14        0.4     0        0         
## t2                  69      63        6       1        2              69      59       10       1        2         
## cap                 870     890      -20      0        0              870     805       65      0        1         
## ne                  0.2     0.1       0.10    0        1              0.2     0.3      -0.07    0        0         
## ct                  0.3     0.2       0.1     0        0              0.3     0.5      -0.2     0       -1         
## bw                  0.2     0.2      0.00     0       NA              0.2     0.2      0.02     0        0         
## cum.n               8       9        -0.5     0        0              8       9        -0.6     0        0         
## ---Overall Test---
##        chisquare df p.value
## ps.pm2         7  7     0.4
## --            11  8     0.2
## ---
## Signif. codes:  0 '***' 0.001 '** ' 0.01 '*  ' 0.05 '.  ' 0.1 '   ' 1

For a very compact representation of the assessment, call summary() on the match, passing along the fitted propensity model as a second argument. If you’ve got RItools loaded, then this will call balanceTest() in the background, reporting the summary chi-square test results.

> summary(ps.pm2, psm)
## Structure of matched sets:
## 1:1 0:1 
##  10  12 
## Effective Sample Size:  10 
## (equivalent number of matched pairs).
## 
## Balance test overall result:
##   chisquare df p.value
##        7.31  8   0.503

Exercise.

Try out {at least 3} different combinations of propensity score and Mahalanobis matching. Identify the matches that gives:

1. the “best balance overall,” as measured by Chi-square statistics;
2. the “best balance overall,” as indicated by the largest standardized difference among the covariates;
3. the best balance on date and cap, as measured by the larger of the standardized differences for these two variables; and
4. the best balance on date and cap, as measured by the larger of the standardized differences for these two variables, among those matches for which the overall imbalance p-value is no more than .1.

Full matching and matching with a varying number of controls

Try out for yourself and compare:

> summary(fullmatch(pr ~ date + cap, data = nuke.nopt))
> summary(fullmatch(pr ~ date + cap, data = nuke.nopt, min = 1))
> summary(fullmatch(pr ~ date + cap, data = nuke.nopt, min = 2, max = 3))

Subclassification before matching

Recall that the data set nuclearplants had 32 observations, 6 of which we excluded. These were plants built under “partial turnkey” guarantees (pt == 1), for which costs are difficult to compare with other plants. We might include the excluded plants by matching them only among themselves. Then we need to subclassify prior to matching.

This is a common and useful operation, and optmatch is designed to help you do it via a strata term in the matching formula.

> pairmatch(pr ~ date + cap + scores(psm), data=nuclearplants)
##    H    I    A    J    B    K    L    M    C    N    O    P    Q    R    S    T 
## <NA>  1.1  1.1 <NA>  1.2 <NA> <NA>  1.4  1.3  1.3 <NA> <NA> <NA>  1.2 <NA>  1.8 
##    U    D    V    E    W    F    X    G    Y    Z    d    e    f    a    b    c 
##  1.7  1.4  1.5  1.5 <NA>  1.6  1.6  1.7 <NA> <NA>  1.9 <NA> 1.10  1.8  1.9 1.10
> pairmatch(pr ~ date + cap + scores(psm) + strata(pt), data=nuclearplants)
##    H    I    A    J    B    K    L    M    C    N    O    P    Q    R    S    T 
## <NA>  0.1  0.1 <NA>  0.2 <NA> <NA>  0.4  0.3  0.3 <NA> <NA> <NA>  0.2 <NA> <NA> 
##    U    D    V    E    W    F    X    G    Y    Z    d    e    f    a    b    c 
##  0.7  0.4  0.5  0.5 <NA>  0.6  0.6  0.7 <NA> <NA>  1.2  1.1  1.3  1.1  1.2  1.3

Distances

You’ll often want to do several variations on a match. It may save computation and typing time to store the distance you’re using to match, if you’re going to re-use that distance. To do so, you’ll have to explicitly separate distance-making and matching, two steps that we’ve merged together thus far. We’ll use the match_on() to create distances.

> cap.dist <- match_on(pr ~ cap, data = nuke.nopt)
> pm1 <- pairmatch(pr ~ cap, data=nuke.nopt)
> pm2 <- pairmatch(cap.dist, data=nuke.nopt)
> all.equal(pm1, pm2, check.attributes = FALSE)
## [1] TRUE
> summary(pm2)
## Structure of matched sets:
## 1:1 0:1 
##   7  12 
## Effective Sample Size:  7 
## (equivalent number of matched pairs).

What does a matching distance look like? Here’s the upper-left corner of one of them:

> round(cap.dist[1:3, 1:3], 1)
##          control
## treatment   H   I   J
##         A 1.8 0.0 0.0
##         B 1.8 0.0 0.0
##         C 0.6 1.2 1.2

(Note the use of square brackets, [ and ], for specifying rows and columns of the distance matrix. If you find that this isn’t working on a distance that you’ve produced, try as.matrix(my.dist)[1:3,1:3] or similar.)

Matching with a caliper of 2 pooled standard deviations on the cap variable:

> round(cap.dist + caliper(cap.dist, 2), 1)
##        control
## treated   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y
##       A 1.8 0.0 0.0 Inf 1.2 Inf 1.3 Inf 1.3 Inf 0.1 1.0 1.4 1.0 0.1 0.7 1.3 Inf
##       B 1.8 0.0 0.0 Inf 1.2 Inf 1.3 Inf 1.3 Inf 0.1 1.0 1.4 1.0 0.1 0.7 1.3 Inf
##       C 0.6 1.2 1.2 1.5 0.0 1.7 0.1 1.2 0.2 1.4 1.1 0.1 0.2 0.1 1.3 0.4 0.2 1.4
##       D 0.7 Inf Inf 0.1 1.4 0.3 1.2 0.1 1.2 0.0 Inf 1.5 1.2 1.5 Inf 1.8 1.2 0.0
##       E 1.7 0.1 0.1 Inf 1.1 Inf 1.2 Inf 1.2 Inf 0.0 1.0 1.3 1.0 0.2 0.7 1.3 Inf
##       F 0.7 1.1 1.1 1.5 0.0 1.8 0.2 1.3 0.2 1.4 1.1 0.1 0.2 0.1 1.2 0.4 0.2 1.4
##       G 0.6 1.2 1.2 1.5 0.0 1.7 0.1 1.2 0.1 1.4 1.1 0.1 0.2 0.1 1.3 0.4 0.2 1.3
##        control
## treated   Z
##       A 0.3
##       B 0.3
##       C 1.5
##       D Inf
##       E 0.4
##       F 1.4
##       G 1.5

Entries of Inf or NaN in a distance matrix are interpreted as forbidden matches. Thus

> pairmatch(cap.dist + caliper(cap.dist, 2), data = nuke.nopt)

matches on cap, insisting that paired units not differ by more than 2 pooled SDs in cap. If you would prefer to set a requirement on how much paired units can differ in cap in its original units, rather than standard units, then you would have to create cap.dist in a somewhat different way. There’s an example on the help page for caliper(). Enter help(caliper) at the R command line.

Trying it out on your own

Below are some suggestions of other data sets you could try this out on.

For another interesting (toy) data set, you can use the “tli” data set in the xtable package.

> install.packages("xtable") # if not already installed
> data(tli, package = "xtable")

You might compare test scores for kids with disadvg=="YES" to those of kids with disadvg=="NO" using propensity matching, in some combination with Mahalanobis matching and caliper matching. A check of propensity overlap may inform your decision as to whether to include a propensity caliper. Be sure to check for balance, and do check the structure of the matched sets.

Three sources of data can be gotten as follows. First, Paul Rosenbaum has collected many of the data sets discussed in his Design of Observational Studies (2010) into the DOS and DOS2 packages.

> install.packages("DOS") # if not already installed
> install.packages("DOS2") # if not already installed
> data(package = "DOS")
> data(package = "DOS2")

Second, the “lalonde” data set, discussed by Lalonde (1986, Am. Econom. Rev.), Dehejia and Wahba (1999, JASA) and Smith and Todd (2005, J. Econom.), is bundled with several R packages, including arm and Matching. To get it:

> install.packages("arm") # if not already installed
> data(lalonde, package = "arm")
> help("lalonde", package = "arm")

Third, the data used by Connors et al (1996, J. Am. Med. Assoc.) to examine costs, benefits and risks associated with right heart catheterization is bundled with Frank Harrell and collaborators’ Hmisc package.

> install.packages("Hmisc") # if not already installed
> Hmisc:::getHdata(rhc, what = "all")